A win-win:
your experience
plus ours.    




We have been supplying high purity
bases for over a decade. During that
time, we have worked closely with
professionals and partners through the
developmental process.

Today we supply numerous compounding
bases and both in-office and retail
products that use lipids.

We welcome the opportunity to work with
you. Our team of chemists and
biophysicists can work with you with
technical information. We know the
physical and chemical properties of our
products.
Our
Microsomes(TM).   

Liposomes are lipid vesicles. They are
formed when thin lipid films are hydrated
and stacks of liquid crystalline bilayers
become fluid and swell. The hydrated lipid
sheets detach during agitation and
self-close to form large multilamellar
vesicles. These vesicles prevent
interaction of water with the hydrocarbon
core of the bilayer at the edges. Once
these particles have formed, the size of
the particles can be reduced through
various methods.

Properties of lipid formulations can vary
depending on the composition--cationic,
anionic, neutral lipid species. The general
procedure is to prepare the lipid for
hydration, hydration with agitation, and
sizing to a homogeneous distribution of
vesicles.

When preparing liposomes with mixed
lipid composition, the lipids must first be
dissolved and mixed in an organic solvent
to assure a homogeneous mixture of
lipids. The production involves a
temperature-controlled, high shear mixing
system to achieve the liposomes of the
desired size.

Lipids and liposomes are used extensively
in many formulations for over two
decades. The most common use is a
liposomal formulation of vitamins A, C and
E. The next wave will be the orally
ingested liposomes which show an effect
on the skin, hair and body.

Liposomes are uniquely suited for delivery
of actives because of their ability to
deliver water-soluble compounds in the
same particle as water-insoluble
compounds.

Topical formulations of liposomal
compounds remain popular. Lipophilic
compounds such as cholesterol and
ceramides, which have been used
topically for many years because they are
lipids found in normal skin tissue, are
easily incorporated into liposomes.

We are now able to supply you with more
sophisticated compounds into liposomes.
Transdemal lipids
and liposomes.   

Phospholipids conjugated to
monomethoxy polyethyleneglycol (PEG)
have been around since 1984 by coupling
carboxy-PEG and purified soy
phosphatidylethanolamine (PE). Since
then the linkage between PEG and PE
has been modified to include esters and
carbamate derivatives.

The technology of liposomeology
continues to be a delivery vehicle for
targeting drugs to a specific biologic site.

Liposome research has made great
strides toward achieving this goal by the
attachment of actives to functionalized
PEG-lipid derivatives.

Our research staff continues to develop
new PEG-lipid derivatives and other
biologically compatible polymeric
compounds.
Bioselect Innovations
THE ULTIMATE COMPOUNDING BASES (TM)
POB 2413
CAPO BEACH, CA 92624
949.630.3844
HRT@HRTBASE.COM
Bioselect Innovations
hrtbase.com
MANY FEATURES IN OUR PRODUCTS ARE PROTECTED BY PROPRIETARY
TECHNOLOGIES AND PATENTS IN THE U.S.A. AND OTHER COUNTRIES.
© 2010 BIOSELECT INNOVATIONS. ALL RIGHTS RESERVED.
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